Dose-Dependent Efficacy and Safety of Tirzepatide for Weight Loss in Non-diabetic Adults With Obesity: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Cureus · 2025 · PMC12234836 · PMID 40630338

Europe PMC DOI

hedged sentence

0.0998

closest p · 2.0× alpha

0.0998

boldest claim

The sentences

did not reach statistical significancep = 0.0998so close (0.05 < p ≤ 0.1)

Each 1 mg increase in tirzepatide dosage was associated with an additional 0.52 kg/m2 reduction in BMI; however, this association did not reach statistical significance (β = -0.5199; 95% CI -1.1390 to 0.0992; p = 0.0998).

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