Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization.

However, examining the expression of genes linked to p53 P loops (that is, genes linked to loops with one of their anchors at the gene’s promoter and the other at a Nutlin-3a induced p53 binding site) did show modest and nominally significant ( P < .05) induction upon Nutlin-3a treatment in seven of the eight cell lines with functional p53 ( Supplementary Fig.

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Permutation tests showed that this overlap is highly significant (Fig. 3F ).

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