Quantitative gradient recalled echo (qGRE) MRI enables in vivo measurement of pre-atrophic neurodegeneration in a mouse model of Alzheimer's disease.

While mean R2* showed a near-significant trend ( Fig. 3b ), both the DMVF, and the R 2 * standard deviation (SD), a measure of value heterogeneity, showed significant increase from 3 to 5mo in Tg4510 mice ( Fig. 3c , p=0.004/p=0.016 DMVF/SD), but not in WT controls (p=0.25).

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