Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial.

5.3 Endo-Histo fusion As envisioned, when fusing the features extracted from endoscopic videos and WSIs, our AI-aided fusion model showed improved performance compared to the endoscopy-only model (DeLong P value < .01) and the histology-only model (although the difference did not reach statistical significance; DeLong P = .35), achieving the highest sensitivity (89.72%, 95% CI, 82.35-94.76), specificity (89.67%, 95% CI, 84.34-93.67) and accuracy (89.69%, 95% CI, 85.61-92.94) in assessing HR ( Table 3 ). 6.

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Discussion There is an increasing trend to adopt a combined endo-HR in UC clinical trials. 20 Our new Endo-Histo fusion model integrates endoscopic videos and histologic WSIs from a clinical trial, outperforming single-modality approaches in assessing HR and response to Mirikizumab at 12 and 52 weeks.

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