Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.

5, H and I ) with a P value trending toward significance ( P = 0.07).

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For the naïve CD8 + T cell population, patient 2 showed a trend of having more naïve CD8 + T cells at the baseline than at the end of cycle 2; however, patients 3 and 6, who had different responses, consistently displayed an opposing trend compared with patient 2, with a positive density shift for CD8-naïve T cells around leukemia cells at the end of cycle 2 from the baseline ( Fig. 4C ).

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