Baicalein from <i>Scutellaria baicalensis</i> mitigates oxidative stress through the IIS pathway in a <i>C. elegans</i> model of ulcerative colitis.

Although baicalein at 50 μM exhibited the highest SOD activity restoration, the difference between 50 μM and 100 μM groups did not reach statistical significance (p > 0.05), suggesting a plateau or concentration-dependent divergence in its regulatory effects on SOD. 3.7 Baicalein modulates p38 MAPK pathway gene expression in DSS-Treated nematodes The MAPK pathway, crucial in UC progression, was assessed in the DSS-induced UC model.

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