Oxytocin Intervention Mitigates Pathological and Behavioral Impairments in APP/PS1 Mice Subjected to Early Social Isolation.

CNS Neurosci Ther · 2025 · PMC12241820 · PMID 40635450

Europe PMC DOI

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0.0900

closest p · 1.8× alpha

0.1000

boldest claim

The sentences

an increasing trendp = 0.09so close (0.05 < p ≤ 0.1)

Furthermore, the number of PSD‐95 puncta in the PFC of the OXT+APP/PS1‐SI group showed an increasing trend compared to the NaCl+APP/PS1‐SI group ( p = 0.09; Figure 6D ). 3.6 OXT Regulates Gut Microbial Homeostasis Fresh fecal samples were collected post‐intervention for 16S rDNA sequencing to investigate the regulatory effects of OXT on gut microbiota homeostasis.

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showed a trendp = 0.10so close (0.05 < p ≤ 0.1)

In emotional behavioral assessments, the APP/PS1‐SI group showed a trend toward reduced time in the center area of the OFT compared to the C57‐GH group ( p = 0.10).

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