Biological sex and age-associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross-sectional study.

Handgrip strength was negatively correlated with age ( r : −0.35; P < 0.001) and positively correlated with transcutaneous O 2 saturation and mean arterial pressure ( r : 0.23 to 0.28; P < 0.04), whereas leg muscle strength was positively correlated with physical activity ( r : 0.31; P = 0.029) and showed a trend toward a negative association between age ( r : −0.25; P = 0.054).

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