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Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers.

Alzheimers Res Ther · 2025 · PMC12243426 · PMID 40635030

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Results Cross-sectional analyses Higher CSF APOE glycosylation is associated with lower AD pathology and better cognitive performance ApoE glycosylation levels from the baseline collection were first examined as a function of the individual APOE isoforms, as our previous work showed a trend of decreasing glycosylation from APOE2 > APOE3 > APOE4 [ 27 , 28 ].

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