A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.

Human T and B lymphocytes develop in these mice, but the mice do not succumb to xeno-GVHD as the differentiated human lymphocytes recognize mouse antigens as “self.” The treatment of these mice with 2B010 resulted in a transient loss of CD25 expression on day 3 on both CD4 + CD25 + Foxp3 − and CD4 + CD25 + Foxp3 + T cells which did not reach statistical significance.

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Treatment with 2B010 resulted in a highly significant depletion of T reg ( Figure 6C ).

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