nominally significantP < 0.01
Lastly, we conducted NetWAS [ 37 ] analysis on nominally significant genes ( P < 0.01) identified from the gene-based analysis, using a relevant tissue network representative of the top gene findings in each cohort.
Lastly, we conducted NetWAS [ 37 ] analysis on nominally significant genes ( P < 0.01) identified from the gene-based analysis, using a relevant tissue network representative of the top gene findings in each cohort.
For the gene- and gene-set enrichment analyses, multiple testing corrections were applied using Bonferroni or Benjamini–Hochberg (BH) methods; only statistically significant or borderline significant associations were reported.
Moreover, gene-based analysis unveiled statistically significant associations for ZFYVE28 and borderline significance for ADAMTS18 , across the West African and East Asian GWAS cohorts.