EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4<sup>+</sup> T cell attachment to a human tri-cell spheroid blood-brain barrier model.

Brain Behav Immun Health · 2025 · PMC12246718 · PMID 40656636

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a possible trendno p-value reported

Our study in mice provided partial support for our observations in human cells, indicating a possible trend toward VE-cadherin downregulation in the mouse brain following ip injection with a biostable synthetic analogue of 7α,25OHC.

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showed a trendno p-value reported

In mice, a single ip injection with a biostable fluoro analogue of 7α,25OHC, the EBI2 agonist, also showed a trend towards downregulation of VE-cadherin in the brain with no such trend observed for Occludin or N-cadherin ( Additional Fig. 4 ) .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4&lt;sup&gt;+&lt;/sup&gt; T cell attachment to a human tri-cell spheroid blood-brain barrier model.

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EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4<sup>+</sup> T cell attachment to a human tri-cell spheroid blood-brain barrier model.