Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma.

An increase in the rate of late effects of radiotherapy due to additional chemotherapy is less well documented and has mostly been described as non-significant or borderline significant in individual studies [ 315 ], [ 415 ], [ 416 ], [ 417 ].

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For mitomycin C, data from two non-randomized studies are available, which only showed a trend towards a survival benefit [ 297 ], [ 339 ].

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From a total of >26 “self-reported” vaginal sex partners (high-risk sexual behaviour; HR-SB) over the entire lifespan, a highly significant association with the occurrence of oropharyngeal cancer was observed (odds ratio 3.1; CI 1.5–6.5), which correlated with the increasing number of partners.

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