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LncRNA RWDD3 Facilitates Leydig Cell Steroidogenesis by Regulating the miR-1388-5p/NPY1R/cAMP Pathway in Yanshan Cashmere Goats.

Animals (Basel) · 2025 · PMC12248551 · PMID 40646785

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Furthermore, the testosterone and intracellular cAMP levels in the pcDNA3.1(+)-lncRWDD3 + 200 ng/mL prolactin group were significantly higher than those in the pcDNA3.1(+)-lncRWDD3 group, and the lncRWDD3 interference group showed a trend toward increased testosterone after 200 ng/mL of prolactin was added, which suggests a facilitating effect of PRL on testosterone secretion ( Figure 5 B).

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