Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F.

In HK2-C mice, these markers were significantly elevated in both types of airway inflammation, whereas in HK2-CKO mice, these markers were markedly reduced, with the exception of Bax/Bcl-2, which exhibited a downward trend but did not reach statistical significance ( Figure 7 A and Figure S6A ).

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