Clinical and Transcriptomic Characterization of Metastatic Hormone-Sensitive Prostate Cancer Patients with Low PTEN Expression.

Int J Mol Sci · 2025 · PMC12249740 · PMID 40650023

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Within the adaptive immune system, PTEN low tumors showed a trend toward higher expression of effector CD8+ cells and B lymphocytes, with overexpression of the immunoglobulin gene signature (IGG signature) [ 24 ], Zhao’s prostate immune-related signature [ 25 ], and exhausted T cell signature.

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