Moloney Murine Leukemia Virus-like Nanoparticles Pseudo-Typed with SARS-CoV-2 RBD for Vaccination Against COVID-19.

While the RBD-specific antibody levels against Omicron before booster vaccination ( Figure 5 D) were generally lower than those directed against RBD Wuhan Hu-1 ( Figure 5 C), the IgG1 reactivity with RBD–Omicron in sera of mice analyzed 28 days after the Omicron booster vaccination (IS7) also increased in six out of eight (75%) mice immunized with FLAG::RBD::GPI omicron VNP; however, the values did not reach statistical significance ( Figure 5 D).

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