PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and monosomy 7.

65 Furthermore, correlation analysis between EZH2 expression level and leukemia cell dependency of 22 human AML cell lines without −7 using DepMap portal showed a trend toward a higher vulnerability to EZH2 knockdown in EZH2 low‐expressor cells as reflected by positive correlation coefficient, albeit statistically insignificant due to small data sample size (Supporting Information S1: Figure 6G ). 66 Therefore, whether EZH2 low‐expressing human MDS/AML cells, including those with EZH2 haploinsufficiency by −7, show a higher vulnerability to pharmacological EZH2 inhibition compared to EZH2 high‐expressors with diploid chromosome 7 should be further investigated based on a larger number of human MDS/AML cell lines and patient samples.

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