Longitudinal immune profiling following autologous hematopoietic stem cell transplantation in multiple sclerosis: insights into immune reconstitution and disease modulation.

In contrast, PD-1 expression in CD8 T cells exhibited variability across patients and did not reach statistical significance ( Figure 8G ). 5–8 Years post-AHSCT At later timepoints the overall phenotype of CD4 and CD8 T cells appeared to normalize, with slight increases in Th1/Th17 subsets and a trend toward reduced CD62L - naïve T cells ( Figures 7 , 8 ).

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