The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity.

J Clin Invest · 2025 · PMC12259257 · PMID 40662362

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did not reach statistical significanceno p-value reported

For example, 3 of the 4 patients homozygous at rs55713253 (TT genotype) required a greater than 50% dose reduction, with a median DI lower than that in patients with the CT genotype, although this difference did not reach statistical significance plausibly because of our limited sample size.

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