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Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout.

Nat Commun · 2025 · PMC12260061 · PMID 40659617

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A clear trend of the dependence of fasting blood glucose level on the optogenetic manipulation was observed. iLight-mediated insulin production in the liver decreased the blood glucose in both WT and Blvra −/− mice, with lower blood glucose levels in Blvra −/− mice (12.93 mM in WT mice versus 9.26 mM in Blvra −/− mice) (Fig. 6f ).

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