Predicting the molecular subtypes of 2021 WHO grade 4 glioma by a multiparametric MRI-based machine learning model.

In the validation set, the clinical model showed substantially lower AUC values (differences of 0.383 and 0.392) compared to the optimal ML model ( p = 0.089) and combined model ( p = 0.063), respectively, though these differences did not reach statistical significance.

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