Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome.

Interestingly, one suggestive signal for tau‐PET on Chr7 ( CRYGN,RHEB /rs12538040, MAF = 0.196, P = 3.80E‐07, β = −0.84) was also nominally significant with the same direction for p‐tau217 ( P = 0.032, β = −0.21). 3.4 Mult‐trait GWAS Multi‐trait GWAS was performed on a subset of 76 participants from ABC‐DS with all four tau biomarker measurements available, aiming to identify pleiotropic loci that simultaneously contribute to all tau biomarkers.

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