Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies.

Mol Ther · 2025 · PMC12265964 · PMID 40057826

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

did not reach statistical significancep = 0.058so close (0.05 < p ≤ 0.1)

The trend toward decrease in AAV8 NAb titers in the CART-19 group did not reach statistical significance ( p = 0.058), but may result from clearance of antigen-antibody complexes after AAV re-administration.

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