Short-Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One-Strike Trigger.

Although the disc height declined in the Loading and DegLd groups (slope: −0.10 ± 0.02 and −0.12 ± 0.04, respectively), the DegUnld group exhibited an increasing trend (slope: 0.06 ± 0.04).

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However, unloading showed a trend towards partial mitigation of the induced degeneration with decreased iNOS and TRPV4 expression, an increased water/sGAG ratio, reduced sGAG release, and recovery of the disc height.

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