Splice-modulating antisense oligonucleotides targeting a pathogenic intronic variant in adult polyglucosan body disease correct mis-splicing and restore enzyme activity in patient cells.

Nucleic Acids Res · 2025 · PMC12266137 · PMID 40671519

Europe PMC DOI

hedged sentence

0.1870

closest p · 3.7× alpha

0.1870

boldest claim

The sentences

showed a trendp = .187not close (p > 0.1)

The last two ASOs, even though not significant, showed a trend for upregulation (ASO 08, p = .187; ASO 74, p = .092) (Fig. 3C and D, and Supplementary Table S2 ).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.