OCNDS core features are conserved across variants, with loop-region mutations driving greater symptom burden.

Front Hum Neurosci · 2025 · PMC12267189 · PMID 40677894

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an observed trendp = 0.11not close (p > 0.1)

While there was an observed trend for loop individuals reporting a higher visual symptom burden, this difference was not statistically significant ( p = 0.11, Supplementary Figure S2J ).

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showed a trendp = 0.11not close (p > 0.1)

Neurological symptoms Individuals with loop variants in CSNK2A1 showed a trend toward a higher number of non-seizure neurological symptoms, though the difference was not statistically significant ( p = 0.11, Figure 5A ).

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