However, consistent with previous research ( Rahal et al., 2021 ; Sloan and Cole, 2021 ), the Type I interferon subcomponent did show a nonsignificant trend toward positive association with HRV in covariate-adjusted analyses (p = 0.097 and 0.078 for SDNN and RMSSD, respectively) whereas inflammatory gene expression showed no such trend for either HRV measure (p = 0.668 and 0.717, respectively).
As in previous research ( Rahal et al., 2021 ; Sloan and Cole, 2021 ), we also found that the overall CTRA effect most strongly involved a positive association between HRV and the Type I interferon subcomponent of the CTRA composite (although this effect did not reach statistical significance in this sample, likely due to the limited sample size available in this study), whereas no trend toward association was observed for the inflammatory subcomponent of the CTRA.