Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling.

Although there was no difference in total eNOS or Akt abundance in pulmonary arteries, the levels of pS1177-eNOS and pT308-Akt showed a trend toward reduced expression levels in pulmonary arteries of ESAM −/− mice ( Fig. 3 , D and E ).

also in 53,322 other papers

We found a nonsignificant trend toward a reduced PAT/PET ratio in ESAM −/− mice ( Fig. 1 , A and B ), and no changes were observed in the Fulton index compared with WT animals ( Fig. 1C ).

also in 5,406 other papers