Treatment of colorectal peritoneal metastases with oxaliplatin induces biomarkers predicting response to immune checkpoint blockade.

Transl Oncol · 2025 · PMC12269567 · PMID 40602034

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0650

boldest claim

The sentences

highly significantp = 1,0e-12actually significant

There was also a highly significant correlation between expression of various B- and T-cell signatures and expression of the immune checkpoint gene TIGIT ( r = 0.80, p = 1,0e-12 and r = 0.91, p = 1.8e-21 respectively) ( Fig. 4 H).

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near-significantp = 0.065so close (0.05 < p ≤ 0.1)

However, expression of the Hallmark gene signature reflecting Hypoxia showed a near-significant ( p = 0.065) decrease in expression following PIPAC (Table S2).

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