Barely Significant
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POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons.

Elife · 2025 · PMC12270483 · PMID 40674128

2
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The sentences

showed a trendno p-value reported
A recent study using whole body MC3RKO mice showed a trend to delayed puberty onset ( Lam et al., 2021 ), suggesting a larger role of melanocortins in the timing of puberty onset.

also in 53,322 other papers

highly significantno p-value reported
This timely study is highly significant in neuroendocrinology research for the following reasons.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.