The impact of biological interventions on health-related quality of life in adults with Crohn's disease: a systematic review with meta-analysis.

Although the subgroup comparison did not reach statistical significance (I 2 = 25%, P = 0.08), a trend toward greater effect was observed in induction trials (CLASSIC I, 32 GAINT, 31 Lichtenstein 2002, 53 SONIC 47 ), where a CMI was achieved (MD 16.37, 95% CI 1.34–31.40; I 2 = 74.5%, P = 0.008; 4 studies; 895 participants).

also in 111,027 other papers