Impact of Sex and Age on Trends of Mortality From Infective Endocarditis in High-Income Countries.

Age-standardized mortality rates across most high-income countries exhibited an increasing trend (average APCs ranging from 1.1%/y [ P < 0.001] in the United Kingdom to 2.4%/y [ P < 0.001] in Italy), while Japan demonstrated a decreasing trend (average APC −2.1%/y, P < 0.001), and the United States demonstrated a constant trend (average APC −0.5%/y, P = 0.14) ( Table 1 , Central Illustration ).

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In the age group ≤49 years, there was a significant trend change in both the United States, where the mortality rates began increasing from 2010 in both sexes (APC 8.0%/y, P < 0.001 in females and 10.0%/y, P = 0.025 in males), and in the United Kingdom, where the mortality rates started rising in males from 2009 (APC 4.3%/y, P = 0.005).

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Age-standardized mortality rates across most high-income countries exhibited an increasing trend (average APCs ranging from 1.1%/y [ P < 0.001] in the United Kingdom to 2.4%/y [ P < 0.001] in Italy), while Japan demonstrated a decreasing trend (average APC −2.1%/y, P < 0.001), and the United States demonstrated a constant trend (average APC −0.5%/y, P = 0.14) ( Table 1 , Central Illustration ).

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