Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation study.

To further validate our findings in the proteome-wide cis -MR, we applied gIVW by including moderately significant ( P < 1 × 10 −4 ) and correlated (r 2 < 0.4) cis-pQTLs as instruments. 34 Out of the 53 associations of lipid fractions with plasma proteins, gIVW produced consistent and statistically significant estimates (Prange = 1.1 × 10 −28 to 0.05) for 43 associations ( Supplementary Table S5A ).

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