Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.

In the APOE ɛ4-unadjusted model, of the genome-wide significant SNPs at the 13 loci, two (15%) were GWS and seven (54%) were nominally significant ( P < 0.05) in HIS; one (7.7%) was GWS and three (23%) were nominally significant in EAS; one (7.7%) each were GWS and nominally significant in AFA; and seven (54%) were at least nominally significant in both NHW and HIS indicating the strongest contribution to the signals by NHW (NHW > HIS > EAS > AFA) (Fig. 2 , Fig.

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