Mortality of metallo-β-lactamase-producing Enterobacterales bacteremias with combined ceftazidime-avibactam plus aztreonam vs. other active antibiotics: a multicenter target trial emulation.

Lancet Reg Health Am · 2025 · PMC12273443 · PMID 40688569

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did not reach statistical significanceno p-value reported

However, the results did not reach statistical significance due to the limited precision. 26 To date, only one clinical trial ( NCT03580044 ) aimed to evaluate the combination of avibactam and aztreonam but was discontinued due to recruitment challenges.

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