Dermatologically Tested Apple-Derived Extracellular Vesicles: Safety, Anti-Aging, and Soothing Benefits for Skin Health.

J Cosmet Dermatol · 2025 · PMC12278024 · PMID 40686092

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did not reach statistical significanceno p-value reported

However, while a slight reduction in average wrinkle depth was noted, this change did not reach statistical significance, indicating that the formulation primarily influences surface‐level skin properties rather than inducing deep tissue remodeling.

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