Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

3 ), but the difference between both conditions did not reach statistical significance and may be explained by the slightly stronger BACE1 inhibition by verubecestat compared to ATV:BACE1 that was also seen for the reduction of CSF Aβ ( Fig. 1 B and Supplemental Fig.

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