Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity.

At first, although several measures of insulin sensitivity including whole-body insulin sensitivity and non-oxidative glucose disposal were increased as a result of intrinsic fiber supplementation, our primary outcome only showed a trend toward significance ( p = 0.085).

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The intrinsic fiber group experienced a mean increase by half a unit on the Bristol stool form scale and a median increase in stool frequency by one defecation per day after the intervention but did not reach statistical significance compared to placebo ( Table S4 ).

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