Gut-tropic α4β7<sup>+</sup>CD8<sup>+</sup> T cells contribute to pancreatic β cell destruction in type 1 diabetes.

However, a downward trend was observed in the MLN of STZ-treated group, although the trend did not reach statistical significance ( Figure 7H ). 4 Discussion In the present study, we have demonstrated an obvious reduction of peripheral gut-tropic T cells through analyzing a cross-sectional cohort of patients with T1D and healthy controls.

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