Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.

Alzheimers Res Ther · 2025 · PMC12288278 · PMID 40708016

Europe PMC DOI

hedged sentences

0.0002

closest p · 0.0× alpha

0.0002

boldest claim

The sentences

nominally significantp = 2.34 × 10 –4actually significant

There was a nominally significant ( p = 2.34 × 10 –4 ) association in males for rs115882880, but no evidence for association ( p > 0.05) in the opposite strata for the other two GWS associations.

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highly significantno p-value reported

The unstratified result is also highly significant, but the magnitude of the association is stronger in females and the maternal proxy cases.

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