Intra-arterial selective hypothermia for acute ischemic stroke neuroprotection: A multicenter pilot trial in China.

Promising numerical differences were observed, including a higher proportion of patients achieving functional independence (mRS 0–1 at 90 days) and a favorable trend in the 90-day ordinal shift analysis.

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Using intention-to-treat analysis, among participants (median age 69 years, 64% [64/100] male, median National Institutes of Health Stroke Scale score 14), the primary outcome did not reach statistical significance, with favorable outcome achieved in 58.0% (29/50) of the IA-LTH group versus 40.0% (20/50) of controls (adjusted relative risk [aRR] of 1.47 (95% CI [0.99, 2.16]; P = 0.055)).

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