Association of Epistatic Effects of lncRNA GAS5, miR-146a, IRAK-1, and miR-155 Genetic Variants with Multiple Sclerosis Risk and Severity.

Mol Neurobiol · 2025 · PMC12289807 · PMID 40234289

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0940

boldest claim

The sentences

highly significantP < 0.0001actually significant

Notably, the interaction between miR - 146a rs2910164 and rs57095329 was highly significant ( P < 0.0001) across several genotype combination levels, conferring a 10- to 100-fold reduced risk of MS. miR - 146a rs57095329 showed significant interactions with IRAK-1 rs3027898 and miR-155 rs767649 ( P < 0.05, before Bonferroni correction).

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did not reach statistical significanceP = 0.094so close (0.05 < p ≤ 0.1)

Although the individual association of this haplotype with MS type did not reach statistical significance ( P = 0.094), the global interaction was significant ( P = 0.0048).

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