A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade.

Sci Rep · 2025 · PMC12289993 · PMID 40707623

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showed a trendno p-value reported

In conclusion, HexaBody-CD27 significantly enhanced T-cell proliferation and cytokine secretion in comparison to one or more benchmark CD27 antibodies and showed a trend towards enhanced T-cell mediated cytotoxicity in vitro compared to IgG1-CD27.

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