We identified a significant reduction in mature beta cells (cluster 0) and concomitant expansion of immature beta cells (cluster 1) in T2D pancreases, accompanied by an increased trend of ER stress-associated beta cell subpopulations, although this did not reach statistical significance (Fig. 4 F).
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Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes.
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