Old Tools in a New Era: The Continued Relevance of Chemotherapy in Pediatric Neuro-Oncology.

Curr Oncol · 2025 · PMC12293580 · PMID 40710220

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The patients randomized in the HD-MTX arm during induction had a significantly better response rate to therapy (63% versus 30% p = 0.038) and showed a trend toward better PFS than those who did not (2-year PFS of 68.2% +/−9.6% vs. 45.8% +/− 13.8%; p = 0.08).

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