Bilirubin Metabolism and Thyroid Cancer: Insights from ALBI and PALBI Indices.

Biomolecules · 2025 · PMC12293926 · PMID 40723913

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borderline significantno p-value reported

However, among men under 50 years of age, the PALBI index incorporating indirect bilirubin showed a borderline significant positive association (HR: 1.09, 95% CI: 1.00–1.18) ( Supplementary Figure S1 ).

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a significant trendno p-value reported

In the quartile analysis (Q1–Q4), indirect bilirubin in women showed statistically significant inverse associations with thyroid cancer in Q2 (HR: 0.84, 95% CI: 0.71–0.99) and Q4 (HR: 0.79, 95% CI: 0.65–0.97), with a significant trend ( p for trend = 0.0221).

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