Comparative Meta-Analysis of Survival, Risk, and Treatment Efficacy in Immunotherapy for Metastatic Melanoma Using Random-, Fixed-, and Mixed-Effects Models.

Results for Adverse Events The prevalence of experiencing at least one AE was significantly higher in the combination therapy group (0.9322, 95% CI: (0.9111, 0.9534)) than in the monotherapy group (0.8194, 95% CI: (0.6562, 0.9152)), with a highly significant difference ( p < 0.001 ).

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Although the time-by-therapy interaction term did not reach statistical significance, the divergence in the predicted survival trajectories suggests a progressively widening gap in long-term benefits.

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