Multi- and Transgenerational Histological and Transcriptomic Outcomes of Developmental TCDD Exposure in Zebrafish (<i>Danio rerio</i>) Ovary.

Consistent with findings from other transgenerational toxicology models, including fish and rodents models exposed to TCDD and other contaminants and stressors, our results showed an increasing trend in DEG levels in the transgenerational generations compared to the direct exposure effects observed in F0 and F1 generations [ 28 , 32 , 80 , 81 , 82 ].

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We observed a weakly significant upregulation in ahr2 (log2FC = 1.140; p = 0.015; FDR = 0.161).

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