In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration.

Sci Rep · 2025 · PMC12297344 · PMID 40715177

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did not reach statistical significanceno p-value reported

Third, in the Rho P23H/+ mouse model, the knockdown of NRL did not reach statistical significance, which may have limited the observed therapeutic effects; optimizing cp-asiNRL variants with improved knockdown efficiency could enhance outcomes in future studies.

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